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Research
Staff: Dr Gary Cowin
RESEARCH FELLOW
Address:
Centre for Magnetic Resonance
Level 2, Gehrmann Laboratories
Research Road
The University of Queensland
Brisbane. QLD. 4072
E-mail address: Gary Cowin
Telephone: +61-7-3365 8378
Fax: +61-7-3365 3833
Home Page: Gary
Cowin
Career Profile:
B.Sc. (Hons), University of New England, 1988
Ph.D., University of Queensland, 1997
Gary Cowin is a member of the MRI Research Group and the areas of
research in which he is involved are centred around applying magnetic
resonance imaging and spectroscopy techniques to answering clinical
questions.
Fat distribution in subjects – determination of liver fat by
spectroscopy and imaging techniques has become an area of research
growth in the previous year. This has included validation pilot studies
against the current clinical standard of histology of biopsy samples
and following changes in weight loss. In addition, abdominal imaging;
to estimate areas of subcutaneous, visceral, intra-peritoneal and
retro-peritoneal fat;, to assess fat deposition in the liver and calf
spectroscopy to differentiate between intra-myocellular and extra-myocellular
fat localisation have been include in some of these studies.
Small animal imaging on the BIO190 has increased dramatically during
2005. New projects have included development of hyperpolarized gas
imaging, labelling therapeutic injectable cells with superparamagnetic
iron oxide, and development of imaging protocols for investigation
of plaque deposition in a mouse alzheimers models.
Installation and beta-testing of PV4 with particular emphasis on parallel
imaging, has also occurred in collaboration with Bruker, Germany on
the Bruker systems at CMR.
Research Interests :
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MRI and MRS investigation of fat localisation
and correlation with insulin resistance |
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Development of parallel acquisition techniques |
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Analysis of MRI gradient performance |
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MRI and MRS investigation of longitudinal changes
in Alzheimers and control subjects |
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13C-NMR isotopomer analysis of renal
glycine, serine and folate metabolism |
Selected Publications:
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Johnston, S.D., Madden, C., Nicolson, V., Cowin,
G., Pyne, M. and Booth, R. (2006). Venipuncture in the short-beaked
echidna. Australian Veterinary Journal 84:66-67. |
» |
Crozier, S., Cowin, G. and Endre,
Z.H. (2004). MR microscopy and microspectroscopy of the intact
kidney. Concepts in Magnetic Resonance 22A(1):
50-59. |
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Wang, D.M., Doddrell, D.M. and Cowin, G. (2004).
A novel phantom and method for comprehensive 3-dimensional measurement
and correction of geometric distortion in magnetic resonance imaging.
Magnetic Resonance Imaging 22(4): 529-542. |
»
|
Zhao, H., Janke, A., Galloway, G.J., Cowin, G.J.
and Doddrell, D.M. Magnetic Resonance in Medicine (Accepted
24/12/03). |
» |
Carey, D.G., Cowin, G.J., Galloway, G.J., Jones,
N.P., Richards, J.C., Biswas, N. and Doddrell, D.M. (2002). Effect
of rosiglitazone on insulin sensitivity, body fat distribution
and liver fat in Type 2 diabetic patients. Obesity Research
10: 1008-1015. |
| » |
Wang, D., Chalk, J.B., Rose, S.E., de Zubicaray,
G., Cowin, G., Galloway, G.J., Barnes, D., Spooner, D., Doddrell,
D.M. and Semple, J. MR image-based measurements of rates of change
in volumes of brain structures. Part II: Application to a study
of Alzheimer's disease and normal aging. Magnetic Resonance
Imaging 20(1): 41-48. |
| » |
Cowin, G.J., Leditschke, I.A., Crozier, S., Brereton,
I.A. and Endre, A.E. (1999). Cortical and medullary betaine-GPC
modulated by osmolality independently of oxygen in the intact
kidney. American Journal of Physiology 277:
F338-F346. |
» |
Cowin, G.J., Leditschke, I.A.,
Crozier, S., Brereton, I.A. and Endre, A.E. (1997). Regional
proton nuclear magnetic resonance spectroscopy differentiates
cortex and medulla in the isolated perfused rat kidney. MAGNA
5: 151-158. |
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Cowin, G.J., Willgoss, D.A. and Endre, Z.H. (1996).
Modulation of glysine-serine interconversion by TCA and glycolytic
intermediates in normoxic and hypoxic proximal tubules. Biochem.
Biophys. Acta 1310: 41-47. |
»
|
Cowin, G.J., Willgoss, D.A., Bartley,
J. and Endre, Z.H. (1996). Serine isotopomer analysis by 13C NMR
defines glycine-serine interconversion in situ in the
renal proximal tubules . Biochem. Biophys. Acta 1310:
32-40. |
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Endre, Z.H., Cowin, G.J., Stewart-Richardson,
P., Cross, M., Willgoss, D.A. and Duggleby, R.G. (1994). 23Na
NMR detects protection by glycine and alanine against hypoxic
injury in the isolated perfused rat kidney. Biochim. Biophys.
Res. Comm. 202: 1639-1644. |
| » |
Cross, M., Endre, Z.H., Stewart-Richardson, P.A.,
Cowin, G.J., Westhuyzen, J. and Fleming, S.J. (1993). 23Na-NMR
detects hypoxic injury in intact kidney: Hypoxic increases in
sodium inhibited by DMSO and DMTU. Magnetic Resonance in Medicine
30: 465-475. |
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