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Research
Staff: Dr Deming Wang
SENIOR RESEARCH FELLOW
Address:
Centre for Magnetic Resonance
Level 2, Gehrmann Laboratories
Research Road
The University of Queensland
Brisbane. QLD. 4072
E-mail address: Deming
Wang
Telephone: +61-7-3365 9066
Fax: +61-7-3365 3833
Home Page: Deming
Wang
Career Profile:
BSc (Honors) Nanjing Normal University, China, 1982
Ph.D (physics) Monash University, 1988.
Deming Wang is a physicist by training. He has been involved in
research on magnetic resonance since 1984 and has worked in electron
spin resonance (ESR), nuclear magnetic resonance and magnetic resonance
imaging (NMR/MRI) and biomedical image analysis. In early years of
his career, he worked as an ESR spectroscopist. A highlight of this
period was the development of a novel computer simulation method which
eventually turned into a commercial product and is now widely used
in the ESR community. In more recent years, his research focus has
been on MRI and biomedical image analysis. He initiated a research
program on image analysis in support of a number of large-scale industry-funded
research projects in which he played a key role. He has approximately
50 peer-reviewed journal articles and is the first author in most
of these papers.
Deming Wang’s current main research focus is on quantitative
MRI. Although MRI has become the most useful imaging modality in radiology,
quantitative MRI is still in its infancy as MRI is known to potentially
contain a variety of image artefacts and these image artefacts can
have significant impact on quantitative analysis. One of the well-known
image artefacts in MRI is the geometric distortion. A novel technique
recently developed by my group for measuring and correcting geometric
distortion in MRI has attracted a great deal of interest world wide.
This technique can effectively remove geometric distortions associated
with MRI hardware imperfection and has become very useful, for example,
for accurate volumetric measurement, or improving precision in radiotherapy
planning and treatments. Our research in this area is not simply to
develop mathematical and computational models for quantitative analysis
in MRI. We develop techniques that can eliminate or minimize the source
of errors and also methods for image quality assessment. Current projects
include correction of geometric distortion in diffusion tensor imaging
and quantitative analysis of prostate MRI and MRSI for improvement
of radiotherapy planning and treatment of prostate cancer.
Deming Wang’s other research interest is in hyperpolarized
(HP) noble gas imaging and spectroscopy. This is a relatively new
area and the University of Queensland is the only place in Australia
where both hyperpolarized 3He and 129Xe can be produced. A number
of research projects are currently being pursued that include developing
novel optical methods for improving HP gas production efficiency;
HP 3He lung imaging for investigation of ventilation strategies in
a rat model of acute lung injury; and HP 129Xe NMR study of mesoporous
materials.
.
Research Interests:
»
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Development of post-processing tools
for quality enhancement of the information content in MR images |
»
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MR image-based quantification for early diagnosis,
monitoring disease progression or evaluation of therapeutic efficacy |
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Image processing |
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Hyperpolarised noble gas MR imaging and spectroscopy |
Selected publications:
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Wang, D.M., Doddrell, D.M. and Cowin,
G. (2004). A novel phantom and method for comprehensive 3-dimensional
measurement and correction of geometric distortion in magnetic
resonance imaging. Magnetic Resonance Imaging 22(4):
529-542. |
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Wang, D.M., Chalk, J.B., Rose, S., de Zubicaray,
G., Cowin, G., Galloway, G.J., Barnes, D., Spooner, D., Doddrell,
D.M. and Semple, J. (2002). MR image-based measurement of rates
of change in volumes of brain structures. Part 2: Application
to a study of Alzheimer's disease and normal aging. Magnetic
Resonance Imaging 20: 41-47. |
| » |
Wang, D.M. and Doddrell, D.M. (2002). MR image-based
measurement of rates of change in volumes of brain structures
Part I: Method and validation. Magnetic Resonance Imaging
20: 27-40. |
| » |
Wang, D.M. and Hanson, G.R. (1995). A new method
for simulating randomly oriented powder spectra in magnetic resonance:
The Sydney Opera House
(SOPHE) method. Journal of Magnetic Resonance Series (A)
117: 1-8. |
| » |
Wang, D.M., Klaassen, A.A.K., Janssen, G.E., de
Boer, E. and Meier, R.J. (1995). The detection of radicals in
strained high-modulus polyethylene (SHMP) fibres. Polymer
36: 4193-4196. |
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Wang, D.M. (1995). The spin susceptibility of
Rb3C60 probed by electron paramagnetic resonance. Solid State
Communications 94: 767-770. |
Patents:
Computer Simulation of Magnetic Resonance Spectra, Wang D and Hanson
G, International Patent Application, PCT/AU96/00534, 1996; US
A Method of Predicting Stroke Evolution using MRI Measures. Rose S,
Chalk J, Janke A, Griffin M, McLachlan G and Wang D, PCT/AU02/00256.
Computer Simulation of Magnetic Resonance Spectra
Wang D, Hanson G, US Patent 6,236,202
Method and Apparatus for Mapping and Correcting Geometric Distortion
in MRI
Wang D and Doddrell D, A PCT paten
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