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Research Staff: Dr
Stephen Rose
SENIOR RESEARCH FELLOW
Address:
MRI Cardiac and Research Centre
B2 Western Annexe
Wesley Hospital
Brisbane Qld 4069
E-mail address: Stephen
Rose
Telephone: +61-7-3232 7480
Fax: +61-7-3232 7121
Home Page: Stephen
Rose
Career Profile:
B.Sc.(Hons), University of Queensland
Ph.D., University of Queensland
Areas of Interest:
Applying novel MRI technology to study:
» Acute stroke
» Alzheimer's disease and mild cognitive impairment
» Psychosis
» Head trauma
» Myocardial viability
» Molecular imaging
» Pharmacological imaging (phMRI)
Research:
My current interests are focused towards the development
and application of novel Magnetic Resonance Imaging (MRI) and spectroscopy
(MRS) methodologies in the fields of medical and biomedical research.
These areas of interest include:
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The study of the evolution of stroke
in humans with diffusion and perfusion weighted echoplanar MRI
and the mathematical modelling of these parameters to predict
final infarct volume. In collaboration with the researchers at
the Queensland Brian Institute, I am also involved in the development
of new MRI contrast agents to enable in vivoimaging of
cells undergoing apoptosis. |
| » |
Longitudinal MR study of patients with Alzheimer's
disease (AD) and mild cognitive impairment (MCI) with spectroscopic
techniques to access metabolic function, and 3D volumetric MRI
techniques in conjunction with neuropsychological assessment to
monitor disease progression. In addition, the investigation of
cerebral perfusion abnormalities and white matter tract degeneration
using diffusion tensor imaging (DTI) in the brains of patients
with probable AD. Similar methods are also being applied to investigate
the extent of neuronal damage in patients with traumatic brain
injury. |
| » |
Studying the loss in connectivity within the brain
using diffusion tensor imaging (DTI) in patients with psychosis. |
| » |
The investigation of ventricular wall mechanics
in the human heart utilising tagged MRI sequences and strain analysis
techniques. The aim of this work is to develop non-invasive methods
of monitoring cardiac function. |
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Investigation of myocardial viability using first
pass and delay contrast enhancement using cardiac perfusion MRI. |
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Development of perfusion based MRI methods to
detect drug receptor sites within the brain. |
Selected Publications:
- Rose, S.E., McMahon, K.L., Janke, A.L., O’Dowd, B., de Zubicaray,
G., Strudwick, M.W. and Chalk, J.B. (2006). Diffusion indices on
magnetic resonance imaging and neuropscyhological performance in
amnestic mild cognitive impairment. Journal of Neurology, Neurosurgery
and Psychiatry 77: 1122-1128.
- Rose, S.E., Janke, A.L., Strudwick, M.W., McMahon, K.L., Chalk,
J.B., Snyder, P. and de Zubicaray, G.I. (2006). Assessment of dynamic
susceptibility contrast cerebral blood flow response to amphetamine
challenge: A human pharmacological MRI (phMRI) study at 1.5 and
4T. Magnetic Resonance in Medicine 55:
9-15
- Rose, S.E., Chalk, J.B., Janke, A.L., Strudwick, M.W., Windus,
L.C., Hannah, D.E., McGrath, J.J. Pantelis, C., Wood, S.J. and Bowry,
B.J. (2006). Evidence of altered prefrontal-thalamic circ
- Rose, S.E., Janke, A.L., Griffin, M., Finnigan, S. and Chalk,
J.B. (2004). Improved prediction of final infarct volume using bolus
delay-corrected perfusion weighted MRI: implications for the ischemic
penumbra. Stroke 35: 2466-2471
- Nelson, C., McCrohon, J., Khafagi, F., Rose, S.E., Leano, R. and
Marwick, T.H. (2004). Impact of scar thickness on the assessment
of viability using dobutamine echo and thallium SPECT. A comparison
with gadolinium late enhancement with magnetic resonance imaging.
Journal of the American College of Cardiology 43:
1248-1256
- Finnigan, S., Rose, S.E., Walsh, M., Griffin, M., Janke, A.L.,
McMahon, K.L., Gillies, R., Strudwick, M.W., Pettigrew, C.M., Semple,
J., Brown, J., Brown, P. and Chalk, J.B. (2004). Correlation of
quantitative EEG with 30 day NIHSS score in acute ischemic stroke:
a comparison with diffusion and perfusion MRI. Stroke 35(4):
899-903
- Parsons, M.W., Barber, P.A., Chalk, J.B., Darby, D.G., Rose, S.E.,
Desmond, P.M., Gerraty, R., Tress, B.M., Wright, P.M., Donnan, G.A.
and Davis, S.M. (2002). Diffusion and perfusion weighted MRI response
to thrombolysis in stroke. Annals of Neurology 51(1):
28-37
- Rose, S.E., Chen, F., Chalk, J.B., Zelaya, F.O., Semple, J. and
Doddrell, D.M. (2000). Loss of connectivity in Alzheimer’s
disease: an evaluation of white matter tract integrity with colour-coded
MR diffusion tensor imaging. Journal of Neurology, Neurosurgery
and Psychiatry 69: 528-530
- Rose, S.E., de Zubicaray, G.I., Galloway, G.J., Chalk, J.B., Wang,
D.M., Semple, J. and Doddrell, D.M. (1999). A 1H MRS study of probable
Alzheimer’s Disease and normal aging: Implications for longitudinal
monitoring of dementia progression. Magnetic Resonance Imaging
17: 291-299
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