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The Centre for Magnetic Resonance (CMR) is a major research centre at the University of Queensland, internationally recognised for excellence in MR research, engineering and education. CMR's collaborative research programs cross interdisciplinary boundaries in addressing questions of fundamental and applied bioscience through innovative application of leading edge MR technology and methodology. CMR strives to facilitate new discovery through the provision of world class instrumentation and expertise in magnetic resonance.
CMR manages major MR instrumentation collectively valued at over $35 million including human MRI scanners, high-field microimaging systems, EPR spectrometers, and high field solution and solids NMR facilities.
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Imaging Seminar:
Download our program for 2009. |
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New published books
- “High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine”, Biological Magnetic Resonance, 2009, 28, Hanson, G.R.; Berliner, L.J. (Eds), Springer, New York.
Metalloproteins are involved in a variety of biologically important processes, including metal ion and oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis and peptide hydrolysis, environmental oxygen, sulphur, and nitrogen cycles, and disease states. High-resolution EPR spectroscopy is crucial in determining the geometric and electronic structural characterization of the redox cofactors in metalloenzymes, which is essential for understanding their reactivity in complex biological systems.This volume, Part I of a two-volume set, covers high-resolution EPR methods, computer simulation, density functional theory, and their application to iron proteins, nickel, and copper enzymes and metals in medicine.
- “Metals in Biology: Applications of High Resolution EPR to Metalloenzymes”, Biological Magnetic Resonance, 2009, 29, Hanson, G.R.; Berliner, L.J. (Eds), Springer, New York, DOI: 10.1007/978-1-4419-1139-1.
Metal ions in biology is an ever expanding area in science and medicine involving metal ions in proteins and enzymes, their biosynthesis, catalysis, electron transfer, metal ion trafficking, gene regulation and disease. While X-ray crystallography has provided snapshots of the geometric structures of the active site redox cofactors in these proteins, the application of high resolution EPR spectroscopy in conjunction with quantum chemistry calculations has enabled, in many cases, a detailed understanding of a metalloenzymes mechanism through investigations of the geometric and electronic structure of the resting, enzyme-substrate intermediates and product complexes. This volume, Part II of a two-volume set demonstrates the application of high resolution EPR spectroscopy in determining the geometric and electronic structure of active site metal ion centers in iron sulfur cluster containing metalloproteins, mononuclear molybdenum metalloenzymes, manganese-containing enzymes and novel metalloproteins.
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| Grant Success |
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CONGRATULATIONS to Dr Gary Cowin for the award of an NHMRC grant.
Pr. F. Thien; A/Pr B. Thompson, A/Pr P. Robinson, Dr B. Harris, Dr G. Cowin Ventilation heterogeneity and airway remodelling in asthma.
The objectives of this project are to: (i) quantitate the ventilation heterogeneity of asthma seen in
hyperpolarised helium lung imaging (ii) correlate ventilation heterogeneity on imaging with
physiological measures of conductive and acinar heterogeneity on multiple breath wash out (MBW)
(iii) compare patterns of ventilation heterogeneity on imaging in asthmatic subjects with and
without fixed airflow obstruction
CONGRATULATIONS to A/Pr Stephen Rose for the award of an NHMRC grant.
A/Pr S. Rose, Pr S. Crozier, Dr O. Salvado, Pr A. Coulthard, Dr P. Thomas, Dr M. Fay Improving the Assessment of Brain Tumour Treatment Outcome using 18F-FDOPA PETMRI Fusion
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CONGRATULATIONS to Dr Katie McMahon who has received an ARC Discovery Project Grant.
Dr DA Copland; Dr KL McMahon; Prof PA Silburn; A/Prof PJ Nathan How does dopamine modulate adult new word learning?
Stroke is a chronic disease of increasing prevalence with increasing age. There is a critical need to develop more
effective treatments of communication disorders in this population. One way of achieving this is to combine certain
drugs with language therapy. Through studying how these drugs influence language, this research will provide
vital knowledge for developing effective forms of pharmacotherapy for adults with language disorders after brain
injury. More effective language rehabilitation can have direct positive consequences on the ability to regain and
maintain employment and social relationships after stroke or brain injury and will address the large and growing
social and economic cost to the nation.
CONGRATULATIONS to Dr Idriss Blakey and Dr Kris Thurecht who were successful in obtaining an ARC Discovery Project Grant.
Dr I Blakey; Dr KJ Thurecht; A/Prof PM Fredericks; Prof C Alexander
Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology
Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007.
Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates.
Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater
sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this
short‑coming the next generation of imaging probes will be developed, which will require fundamental
investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe
functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.
CONGRATULATIONS to Dr Greig de Zubicaray who has received an ARC Discovery Project Grant for his research project entitled "How the brain produces speech"
Speech production is a fundamental ability that enables human interaction through language. Brain injuries impair
this ability, with profound negative consequences for the individual and their immediate family and friends. This
project will increase our understanding of the brain mechanisms involved in producing speech by using
state‑of‑the‑art brain imaging techniques. The findings will inform future clinical research and improve the advice
given to clinicians, patients and the broader community about the nature of language production and its
impairments and ultimately the treatment of speech disorders.
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CONGRATULATIONS to Dr Viktor Vegh, Dr Greg Pierens, Professor David Reutens and Dr Deming Wang from the Centre for Magnetic Resonance and the Centre for Advanced Imaging who have received a Round 3 Bill & Melinda Gates Foundation Grand Challenges Exploration grant.
Malaria Detection using Earth's magnetic field:
The project deals with the creation of new tools to accelerate the eradication of malaria. The funds will be used to research and develop a screening test for malaria that combines Nuclear Magnetic Resonance spectroscopy and magnetic separation of blood fractions. The method assays blood hemozoin concentration in magnetic and non-magnetic fractions of malarial blood. The expected project outcome is a portable device capable of screening for malaria.
More information on UQNews. |
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CONGRATULATIONS to Dr Greig de Zubicaray who was successful in obtaining 2010 ARC fundings for his Future Fellowship entitled "The articulate brain".
Dr de Zubicaray said; "The aim of this program of research is to increase our understanding of the brain mechanisms involved in language production and comprehension by using a combination of state-of-the-art brain imaging, computational modelling, behavioural and genetics methods. The objectives are to inform clinical research and improve the advise given to clinicians, patients and the broader community about the nature of language and its impairments and ultimately the treatment of language disorders."
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Short Courses - Spectroscopy
A three day course was held on the 11, 12 and 13 of September at the Wesley Hospital for both the novice and the established spectroscopists. Comments made by the students were very positive;
"It was good to be in a small group", "Excellent content", "Good range of info - from acquisition to analysis", "The tutors were all so friendly, easy to approach and great at answering questions!", "Great course! I would definitely recommend it to others"
Visit our Short Course webpage for the 2010 Short course calendar. |
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